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KMID : 0365819740140020125
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Journal of Pusan Medical College
1974 Volume.14 No. 2 p.125 ~ p.135
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Effect of Prostaglandin E₁on the Intraocular Pressure and the Pupil of the Rabbit
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Abstract
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This study was aimed to investigate the effects of Prostaglandin E,(PGE,) as well as several adrenergic and adrenergic blocking agents on the intraocular pressure and pupil of rabbit.
The results were summerized as follows:
1. Intraocular pressure was most significantly fallen during 3 to 4 hour period after instillation of epinephrine, norepinephrine or isoproterenol while the pupil was most remarkably dilated during 30 to 60 minute period after its instillation.
2. The intravenous injection of propranolol, 2.0 mg/kg body weight, lowered slightly the intraocular pressure, but the injection of phenoxybenzamine, 2. 0 mg/kg body weight, showed significant lowering effect on intraocular pressure while the latter in the dose of 0. 5 mg/kg body weight showed minimal. The pupil, however, responded poorly either to propranolol or phenoxybenzamine.
3. Pretreatment with propranolol, 2. 0 mg/kg body weight, did not block the effects of epinephrine or norepinephrine on lowering intraocular tension and dilating pupil but blocked the lowering action of intraocular pressure by isoproterenol. On the other hand, pretreatment with phenoxybenzamine, 0. 5 mg/kg body weight, blocked satisfactorily the effects of epinephrine and norepinephrine on lowering intraocular pressure and dilating pupil but not those of isoprotererenol.
4. PGE,, injected intracamerally, caused prominent elevation of intraocular pressure and miosis and the elevation was less prominent when pretreated with epinephrine or norepinephrine. The elevation of intraocular pressure by PGE1 in which case the eye was pretreated with phenoxybenzamine, then folwed by the instillation of epinephrine or norepinephrine, was more remarkable than that by PGE, alone. In another e::periment by replacing piienuxylienzamine with propranolol in the above noted procedure, the elevation of intraocular pressure was less remarkable than that in case of PGE, alone, As far as pupil was concerned, the miotic effect of PGE, was not altered by pretreatment with either phenoxybenzamine or propranolol.
Therefore it could be thought that the point of action of intraocular pressure increase by PGE, was related with the production of aqueous humor due to increased blood flow of the ciliary body.
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